Cynthia grew up with an older brother, Carlos, who has Prader-Willi Syndrome. She did not learn of his actual diagnosis until their mother passed away and she became his guardian. These past few years she has really stepped into her role as caretaker, researching and learning about this disorder and how she can best help her brother. He has lost 200 lbs, attends an adult day center where he plays sports and has a friend who shares his diagnosis and is still a companion to Cynthia. As she says, “We need each other”. In this conversation, Cynthia shares with us her story. We discuss the differences in relationships between parent and child, and siblings, and the expectations and behaviors that result from that. Cynthia also shares with us some advice on how to prepare our children for the possibility of becoming guardians of their siblings. Cynthia is an inspiring woman, a delight to speak with and a beautiful example of the power of family.